Based on the Half-Life / Portal universe.

Assumes familiarity with canon — including Portal 2: Lab Rat and Portal Stories: Mel — but is not always faithful to canon.

If something seems obviously wrong or different from what canon material depicts or implies, it's probably on purpose.

I haven't played Half-Life: Alyx and don't know if it shows anything that would have ramifications for this setting. Any deviations from its canon are unintentional, and may or may not be changed after I play it.